Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.46 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018185 | 0.92 | RAB9A (0.55) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL9018240 | 0.90 | BCL2L1 (0.52) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL9018050 | 0.90 | P4HTM (0.44) | HPGDP4HTMMEN1KMT2A | |
| SCHEMBL9018429 | 0.89 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2POLBP4HTM | |
| SCHEMBL9017994 | 0.89 | EGFR (0.41) | NPC1RAB9ASMN1; SMN2HPGDP4HTM | |
| SCHEMBL9018116 | 0.89 | RAB9A (0.50) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL9018180 | 0.89 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL9018251 | 0.88 | MAPT (0.49) | NPC1RAB9ASMN1; SMN2BCL2L1MCL1 | |
| SCHEMBL7862722 | 0.88 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2HPGDPOLB | |
| SCHEMBL9018204 | 0.88 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2POLBP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |