Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018266 | 0.94 | HPGD (0.47) | EGFRP4HTMALDH1A1KDM4EMAPT | |
| SCHEMBL9018050 | 0.93 | P4HTM (0.44) | EGFRP4HTMALDH1A1KDM4EKMT2A | |
| SCHEMBL9018041 | 0.93 | P4HTM (0.44) | EGFRP4HTMALDH1A1KDM4EMAPT | |
| SCHEMBL7867703 | 0.90 | EGFR (0.45) | EGFRP4HTMALDH1A1KDM4EMAPT | |
| SCHEMBL9018337 | 0.89 | ALDH1A1 (0.45) | EGFRP4HTMALDH1A1KDM4EMAPT | |
| SCHEMBL9018017 | 0.89 | EGFR (0.45) | EGFRP4HTMKMT2AEPHX2SMN1; SMN2 | |
| SCHEMBL9018048 | 0.89 | NPC1 (0.52) | P4HTMMAPTKMT2AHPGDNPC1 | |
| SCHEMBL9018420 | 0.89 | P4HTM (0.39) | EGFRP4HTMALDH1A1KDM4EMAPT | |
| SCHEMBL9018236 | 0.88 | HPGD (0.50) | EGFRP4HTMALDH1A1KDM4EMAPT | |
| SCHEMBL9018169 | 0.88 | CA2 (0.50) | EGFRP4HTMALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |