Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017994 | 0.93 | EGFR (0.41) | P4HTMEGFRKMT2AHPGDKDM4E | |
| SCHEMBL9018337 | 0.90 | ALDH1A1 (0.45) | P4HTMEGFRKMT2ATP53KDM4E | |
| SCHEMBL9018017 | 0.90 | EGFR (0.45) | P4HTMGABRA5EGFRKMT2AMEN1 | |
| SCHEMBL9018048 | 0.90 | NPC1 (0.52) | P4HTMKMT2AMEN1HPGD | |
| SCHEMBL9018266 | 0.90 | HPGD (0.47) | P4HTMEGFRKMT2AMEN1HPGD | |
| SCHEMBL9018169 | 0.89 | CA2 (0.50) | P4HTMEGFRTP53KDM4EALDH1A1 | |
| SCHEMBL9018041 | 0.88 | P4HTM (0.44) | P4HTMEGFRKMT2AMEN1HPGD | |
| SCHEMBL7867912 | 0.88 | EGFR (0.47) | P4HTMGABRA5EGFRKMT2AMEN1 | |
| SCHEMBL9018429 | 0.88 | NPC1 (0.51) | P4HTMKMT2AMEN1TP53KDM4E | |
| SCHEMBL9018202 | 0.87 | P4HTM (0.43) | P4HTMGABRA5EGFRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |