Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018526 | 0.92 | SMN1; SMN2 (0.45) | SMN1; SMN2P4HTMCASP3HTTOPRM1 | |
| SCHEMBL9018408 | 0.92 | SMN1; SMN2 (0.46) | SMN1; SMN2P4HTMCASP3HTTOPRM1 | |
| SCHEMBL9018075 | 0.91 | SMN1; SMN2 (0.43) | SMN1; SMN2P4HTMCASP3HTTMEN1 | |
| SCHEMBL9018331 | 0.91 | RAB9A (0.40) | SMN1; SMN2P4HTMCASP3HTTMEN1 | |
| SCHEMBL9018122 | 0.91 | HTT (0.50) | P4HTMHTTOPRM1OPRD1OPRK1 | |
| SCHEMBL9018053 | 0.90 | CA2 (0.40) | SMN1; SMN2P4HTMCASP3MEN1KMT2A | |
| SCHEMBL9018066 | 0.90 | RAB9A (0.48) | SMN1; SMN2P4HTMHTTOPRM1OPRD1 | |
| SCHEMBL9018286 | 0.90 | GABRA5 (0.40) | SMN1; SMN2P4HTMCASP3HTTMEN1 | |
| SCHEMBL9018203 | 0.90 | EGFR (0.42) | P4HTMOPRM1OPRD1OPRK1GABRA5 | |
| SCHEMBL9018177 | 0.88 | RAB9A (0.40) | SMN1; SMN2CASP3HTTMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |