Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | FBP1 | P09467 | 5/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018075 | 0.97 | SMN1; SMN2 (0.43) | SMN1; SMN2KMT2AFBP1RXFP1BCL2L1 | |
| SCHEMBL9018126 | 0.93 | SMN1; SMN2 (0.40) | CA2SMN1; SMN2NAAAKMT2AFBP1 | |
| SCHEMBL9018042 | 0.92 | SMN1; SMN2 (0.43) | CA2SMN1; SMN2NAAAKMT2AFBP1 | |
| SCHEMBL9018286 | 0.92 | GABRA5 (0.40) | SMN1; SMN2KMT2AP4HTMCASP3MEN1 | |
| SCHEMBL9018093 | 0.91 | ALDH1A1 (0.42) | SMN1; SMN2P4HTML3MBTL1HDAC6 | |
| SCHEMBL9018087 | 0.91 | CA2 (0.47) | CA2SMN1; SMN2NAAAKMT2ARXFP1 | |
| SCHEMBL9018378 | 0.90 | RAB9A (0.43) | SMN1; SMN2P4HTMHDAC6 | |
| SCHEMBL9018177 | 0.90 | RAB9A (0.40) | SMN1; SMN2KMT2AFBP1L3MBTL1CASP3 | |
| SCHEMBL9018331 | 0.90 | RAB9A (0.40) | SMN1; SMN2KMT2AP4HTMCASP3MEN1 | |
| SCHEMBL9018055 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2KMT2ABCL2L1MCL1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |