Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.56 |
| ▸ | HTR1A | P08908 | 6/20 | 0.56 |
| ▸ | DRD3 | P35462 | 5/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | HRH1 | P35367 | 3/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018113 | 0.86 | HTR2A (0.54) | HTR2ADRD2HTR1ADRD4ADRA1A | |
| SCHEMBL7823924 | 0.82 | HTR2A (0.58) | HTR2ADRD2HTR1ADRD3DRD4 | |
| SCHEMBL8651520 | 0.82 | HTR2A (0.59) | HTR2ADRD2HTR1ADRD4ADRA1A | |
| SCHEMBL7815509 | 0.81 | HTR2A (0.61) | HTR2ADRD2HTR1ADRD4ADRA1A | |
| SCHEMBL7817256 | 0.80 | HTR2A (0.56) | HTR2ADRD2HTR1ADRD4ADRA1A | |
| SCHEMBL14493421 | 0.79 | DRD4 (0.49) | HTR2ADRD2DRD3SIGMAR1DRD4 | |
| SCHEMBL4442569 | 0.79 | HTR1A (0.65) | HTR2ADRD2HTR1ADRD3DRD4 | |
| SCHEMBL7817436 | 0.79 | HTR2A (0.56) | HTR2ADRD2HTR1ADRD4ADRA1A | |
| SCHEMBL9018168 | 0.78 | ADRA1A (0.49) | HTR2ADRD2HTR1ADRD4ADRA1A | |
| SCHEMBL9018034 | 0.78 | HTR2A (0.56) | HTR2ADRD2HTR1ADRD4ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570850-B1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0570850-A1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5240927-A | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-08-31 | — | — | US | disclosed |