Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.56 |
| ▸ | DRD2 | P14416 | 6/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018038 | 0.81 | DRD2 (0.54) | HTR2ADRD2ADRA1AHTR1ADRD4 | |
| SCHEMBL9018059 | 0.78 | HTR2A (0.56) | HTR2ADRD2ADRA1AHTR1ADRD4 | |
| SCHEMBL8556374 | 0.78 | DRD2 (0.63) | HTR2ADRD2ADRA1AHTR1AEPHX2 | |
| SCHEMBL7824411 | 0.76 | ADRA1A (0.70) | HTR2ADRD2ADRA1AHTR1ADRD4 | |
| SCHEMBL9018128 | 0.74 | ADRA1A (0.52) | HTR2ADRD2ADRA1AHTR1ADRD4 | |
| SCHEMBL9596902 | 0.74 | ADRA1A (0.51) | HTR2ADRD2ADRA1AHTR1ADRD4 | |
| SCHEMBL11926259 | 0.74 | EPHX2 (0.69) | TSHREPHX2 | |
| SCHEMBL9018047 | 0.73 | DRD4 (0.57) | HTR2ADRD2ADRA1AHTR1ADRD4 | |
| SCHEMBL13809537 | 0.73 | ADRA1A (0.65) | HTR2ADRD2ADRA1AHTR1ADRD4 | |
| SCHEMBL9018113 | 0.72 | HTR2A (0.54) | HTR2ADRD2ADRA1AHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0570850-B1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0570850-A1 | Benzo(b)thiophen-3-yl-piperazines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5240927-A | Benzo[β]thiophen-3-yl piperazines as antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-08-31 | — | — | US | disclosed |