Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018440 | 0.90 | POLB (0.49) | TGM2POLBTDP1ROCK2ROCK1 | |
| SCHEMBL9018210 | 0.89 | SMN1; SMN2 (0.45) | TGM2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9140719 | 0.88 | TGM2 (0.48) | TGM2POLBTDP1ROCK2ROCK1 | |
| SCHEMBL9018062 | 0.88 | SMN1; SMN2 (0.45) | TGM2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9018159 | 0.88 | KMT2A (0.49) | TGM2ROCK2MEN1KMT2AALDH1A1 | |
| SCHEMBL9018483 | 0.87 | GABRA5 (0.43) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL9018157 | 0.86 | POLB (0.47) | TGM2POLBTDP1ROCK2ROCK1 | |
| SCHEMBL9018502 | 0.86 | GABRA5 (0.43) | PDE4APDE4BPDE4CPDE4DKMT2A | |
| SCHEMBL9018234 | 0.86 | POLB (0.46) | TGM2POLBTDP1ROCK2ROCK1 | |
| SCHEMBL9018058 | 0.86 | ACACB (0.43) | TGM2ROCK2NAMPTALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |