Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018508 | 0.98 | HSP90AA1 (0.42) | ACACBNPC1RAB9ATGM2NAMPT | |
| SCHEMBL9018210 | 0.95 | SMN1; SMN2 (0.45) | NPC1RAB9ATGM2OPRK1OPRM1 | |
| SCHEMBL9018062 | 0.94 | SMN1; SMN2 (0.45) | NPC1RAB9ATGM2OPRK1OPRM1 | |
| SCHEMBL9018083 | 0.91 | SCN3A (0.46) | RAB9AOPRK1OPRM1EPHX2P4HTM | |
| SCHEMBL9018131 | 0.89 | HPGD (0.41) | ACACBEPHX2P4HTMALDH1A1CYP3A4 | |
| SCHEMBL9018268 | 0.89 | RAB9A (0.46) | NPC1RAB9AEPHX2P4HTMROCK2 | |
| SCHEMBL9139029 | 0.88 | P4HTM (0.48) | NPC1RAB9ATGM2NAMPTOPRK1 | |
| SCHEMBL9018430 | 0.88 | ACACB (0.40) | ACACBEPHX2P4HTMALDH1A1CYP3A4 | |
| SCHEMBL9018187 | 0.88 | CA2 (0.45) | ACACBEPHX2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9018540 | 0.88 | RAB9A (0.47) | NPC1RAB9AEPHX2P4HTMROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |