Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018210 | 0.92 | SMN1; SMN2 (0.45) | ALDH1A1LMNAMAPTHTTNPSR1 | |
| SCHEMBL9018062 | 0.91 | SMN1; SMN2 (0.45) | ALDH1A1LMNAMAPTHTTNPSR1 | |
| SCHEMBL9018058 | 0.91 | ACACB (0.43) | EPHX2ALDH1A1HTTNPSR1P4HTM | |
| SCHEMBL9018508 | 0.90 | HSP90AA1 (0.42) | ALDH1A1HTTNPSR1P4HTMOPRM1 | |
| SCHEMBL9018501 | 0.88 | CXCR1 (0.42) | LMNAMAPTP4HTMOPRM1OPRK1 | |
| SCHEMBL9018268 | 0.87 | RAB9A (0.46) | EPHX2ALDH1A1P4HTMRAB9ASMN1; SMN2 | |
| SCHEMBL9140731 | 0.87 | P4HTM (0.51) | SCN3AALDH1A1LMNAMAPTHTT | |
| SCHEMBL9018540 | 0.86 | RAB9A (0.47) | EPHX2ALDH1A1P4HTMRAB9ASMN1; SMN2 | |
| SCHEMBL9018390 | 0.86 | CA1 (0.44) | EPHX2ALDH1A1LMNAMAPTHTT | |
| SCHEMBL9018303 | 0.86 | MCL1 (0.51) | P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |