Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018268 | 0.99 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2HPGDBCL2L1 | |
| SCHEMBL9018062 | 0.90 | SMN1; SMN2 (0.45) | RAB9ANPC1SMN1; SMN2HPGDP4HTM | |
| SCHEMBL9018502 | 0.90 | GABRA5 (0.43) | NPC1SMN1; SMN2P4HTMPDE4APDE4B | |
| SCHEMBL9018210 | 0.89 | SMN1; SMN2 (0.45) | RAB9ANPC1SMN1; SMN2HPGDP4HTM | |
| SCHEMBL9018483 | 0.89 | GABRA5 (0.43) | SMN1; SMN2P4HTMPDE4APDE4BPDE4C | |
| SCHEMBL9018550 | 0.89 | SMN1; SMN2 (0.44) | RAB9ANPC1SMN1; SMN2HPGDBCL2L1 | |
| SCHEMBL9018058 | 0.88 | ACACB (0.43) | RAB9ANPC1SMN1; SMN2ROCK2P4HTM | |
| SCHEMBL9018239 | 0.87 | ALDH1A1 (0.40) | RAB9ANPC1SMN1; SMN2HPGDP4HTM | |
| SCHEMBL9139907 | 0.87 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2HPGDBCL2L1 | |
| SCHEMBL9018508 | 0.87 | HSP90AA1 (0.42) | RAB9ANPC1P4HTMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |