Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018134 | 0.92 | RAB9A (0.49) | HTTALDH1A1POLBRAB9AHDAC8 | |
| SCHEMBL9018147 | 0.91 | RAB9A (0.44) | HTTALDH1A1POLBEPHX2RAB9A | |
| SCHEMBL9018099 | 0.90 | SMN1; SMN2 (0.43) | HTTEPHX2RAB9ALMNAP4HTM | |
| SCHEMBL9018296 | 0.90 | HTT (0.55) | HTTALDH1A1GAAHSD17B10POLB | |
| SCHEMBL9018341 | 0.88 | RAB9A (0.50) | POLBRAB9AHDAC8HDAC6HDAC2 | |
| SCHEMBL9018272 | 0.88 | RAB9A (0.41) | HTTALDH1A1RAB9ALMNAP4HTM | |
| SCHEMBL9018213 | 0.88 | SMN1; SMN2 (0.45) | HTTGAARAB9ALMNAP4HTM | |
| SCHEMBL9018122 | 0.87 | HTT (0.50) | HTTALDH1A1GAAHSD17B10POLB | |
| SCHEMBL9018432 | 0.87 | HTT (0.52) | HTTALDH1A1GAAHSD17B10POLB | |
| SCHEMBL9018238 | 0.86 | KMT2A (0.43) | GAARAB9AP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |