Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018134 | 0.95 | RAB9A (0.49) | RAB9AALDH1A1NPC1SMN1; SMN2TP53 | |
| SCHEMBL9018213 | 0.93 | SMN1; SMN2 (0.45) | RAB9ASMN1; SMN2MAPTKMT2AMEN1 | |
| SCHEMBL9018089 | 0.91 | HTT (0.51) | RAB9AALDH1A1HDAC2HDAC8HDAC6 | |
| SCHEMBL9017995 | 0.91 | KMT2A (0.43) | RAB9AALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL9018238 | 0.91 | KMT2A (0.43) | RAB9ASMN1; SMN2MAPTKMT2AP4HTM | |
| SCHEMBL9018085 | 0.91 | RAB9A (0.47) | RAB9AALDH1A1NPC1SMN1; SMN2TP53 | |
| SCHEMBL9018341 | 0.89 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2HDAC2HDAC8 | |
| SCHEMBL9018272 | 0.89 | RAB9A (0.41) | RAB9AALDH1A1SMN1; SMN2TP53MAPT | |
| SCHEMBL9018114 | 0.89 | HDAC2 (0.40) | RAB9AHDAC2HDAC8HDAC6POLB | |
| SCHEMBL9018007 | 0.88 | ALDH1A1 (0.46) | RAB9AALDH1A1NPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |