Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018206 | 0.97 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2OPRK1EPHX2 | |
| SCHEMBL9018507 | 0.95 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2OPRK1P4HTM | |
| SCHEMBL9018179 | 0.93 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2OPRK1EPHX2 | |
| SCHEMBL9018480 | 0.92 | MEN1 (0.47) | NPC1RAB9ASMN1; SMN2OPRK1P4HTM | |
| SCHEMBL9018010 | 0.92 | RAB9A (0.44) | NPC1RAB9ASMN1; SMN2EPHX2P4HTM | |
| SCHEMBL9018142 | 0.91 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2OPRK1EPHX2 | |
| SCHEMBL9018143 | 0.90 | SCN3A (0.48) | OPRK1EPHX2P4HTMNAMPTOPRM1 | |
| SCHEMBL9018225 | 0.90 | HSP90AA1 (0.47) | NPC1RAB9ASMN1; SMN2OPRK1EPHX2 | |
| SCHEMBL9018218 | 0.90 | OPRK1 (0.45) | NPC1RAB9ASMN1; SMN2OPRK1EPHX2 | |
| SCHEMBL9018465 | 0.89 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2EPHX2P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |