Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018499 | 0.97 | OPRK1 (0.44) | NPC1RAB9ASMN1; SMN2OPRK1MAPT | |
| SCHEMBL9017989 | 0.95 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2OPRK1MAPT | |
| SCHEMBL9018218 | 0.93 | OPRK1 (0.45) | NPC1RAB9ASMN1; SMN2OPRK1MAPT | |
| SCHEMBL9018380 | 0.92 | MEN1 (0.46) | NPC1RAB9ASMN1; SMN2OPRK1MAPT | |
| SCHEMBL9018378 | 0.92 | RAB9A (0.43) | NPC1RAB9ASMN1; SMN2OPRK1MAPT | |
| SCHEMBL9018141 | 0.91 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2OPRK1MAPT | |
| SCHEMBL9018179 | 0.91 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2OPRK1EPHX2 | |
| SCHEMBL9018001 | 0.91 | OPRK1 (0.44) | NPC1RAB9ASMN1; SMN2OPRK1MAPT | |
| SCHEMBL9018148 | 0.90 | CA2 (0.42) | NPC1RAB9AOPRK1EPHX2P4HTM | |
| SCHEMBL9018093 | 0.90 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2OPRK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |