Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018257 | 0.91 | MMP2 (0.43) | ALDH1A1OPRM1OPRD1OPRK1BCL2L1 | |
| SCHEMBL9018200 | 0.91 | ALDH1A1 (0.48) | ALDH1A1P4HTMPOLBGAA | |
| SCHEMBL9018305 | 0.91 | BCL2L1 (0.46) | ALDH1A1OPRM1OPRD1OPRK1BCL2L1 | |
| SCHEMBL9018051 | 0.90 | ALDH1A1 (0.45) | ALDH1A1OPRM1OPRD1OPRK1P4HTM | |
| SCHEMBL9018123 | 0.89 | OPRM1 (0.43) | ALDH1A1OPRM1OPRD1OPRK1BCL2L1 | |
| SCHEMBL9018104 | 0.89 | BCL2L1 (0.48) | OPRM1OPRD1OPRK1BCL2L1MCL1 | |
| SCHEMBL9018243 | 0.89 | ALDH1A1 (0.50) | ALDH1A1P4HTMRAB9APOLB | |
| SCHEMBL9137443 | 0.87 | P4HTM (0.48) | ALDH1A1BCL2L1MCL1P4HTMRAB9A | |
| SCHEMBL9018076 | 0.87 | ALDH1A1 (0.49) | ALDH1A1OPRM1OPRD1OPRK1BCL2L1 | |
| SCHEMBL9018226 | 0.86 | CA1 (0.48) | ALDH1A1OPRM1OPRD1OPRK1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |