Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018116 | 0.93 | RAB9A (0.50) | RAB9ANPC1SMN1; SMN2HPGDPOLB | |
| SCHEMBL9018397 | 0.91 | P4HTM (0.41) | HPGDMEN1KMT2AP4HTMALDH1A1 | |
| SCHEMBL9018513 | 0.90 | NPC1 (0.47) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9018180 | 0.90 | RAB9A (0.52) | RAB9ANPC1SMN1; SMN2HPGDPOLB | |
| SCHEMBL9018185 | 0.90 | RAB9A (0.55) | RAB9ANPC1SMN1; SMN2HPGDPOLB | |
| SCHEMBL9018091 | 0.89 | MEN1 (0.44) | RAB9ANPC1SMN1; SMN2BCL2L1MCL1 | |
| SCHEMBL9018299 | 0.89 | EPHX2 (0.38) | RAB9ANPC1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL9018218 | 0.89 | OPRK1 (0.45) | RAB9ANPC1SMN1; SMN2POLBMEN1 | |
| SCHEMBL9018422 | 0.88 | CA2 (0.41) | RAB9ANPC1KMT2AP4HTMALDH1A1 | |
| SCHEMBL9018001 | 0.88 | OPRK1 (0.44) | RAB9ANPC1SMN1; SMN2HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |