Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018019 | 0.92 | LMNA (0.42) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9018063 | 0.88 | LMNA (0.44) | LMNACYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL9018267 | 0.88 | HSD17B10 (0.45) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9140620 | 0.88 | LMNA (0.47) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9018390 | 0.87 | CA1 (0.44) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9018388 | 0.87 | LMNA (0.41) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9018079 | 0.86 | ALDH1A1 (0.42) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9018393 | 0.86 | CXCR1 (0.47) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9018166 | 0.86 | POLB (0.46) | LMNACYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9018067 | 0.86 | LMNA (0.40) | LMNACYP3A4CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |