Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710009 | 0.81 | PARP1 (0.54) | PDE10ALMNAKMT2AMEN1CCR1 | |
| SCHEMBL6196701 | 0.81 | CCR1 (0.63) | PDE10ALMNAKMT2AMEN1CCR1 | |
| SCHEMBL7806536 | 0.81 | CCR1 (0.63) | PDE10ALMNAKMT2AMEN1CCR1 | |
| SCHEMBL31648790 | 0.79 | CCR1 (0.56) | PDE10ALMNACCR1ALDH1A1PARP1 | |
| SCHEMBL8944345 | 0.79 | CCR1 (0.56) | PDE10ALMNACCR1ALDH1A1PARP1 | |
| SCHEMBL9018925 | 0.78 | FAAH (0.43) | PDE10ALMNAKMT2AMEN1CCR1 | |
| SCHEMBL12844021 | 0.78 | PDE10A (0.48) | PDE10ALMNAKMT2AMEN1CCR1 | |
| SCHEMBL14911977 | 0.78 | PDE10A (0.45) | PDE10ALMNAKMT2AMEN1CCR1 | |
| SCHEMBL4851483 | 0.77 | AR (0.41) | PDE10ALMNAKMT2AMEN1CCR1 | |
| SCHEMBL2781605 | 0.77 | METAP2 (0.53) | PDE10ALMNAKMT2AMEN1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414019-B1 | Subsituted N-(quinolin-2-yl-methoxy)benzylsulfonylureas | BAYER AG (DE) | 1996-05-29 | — | — | EP | disclosed |
| EP-0344519-B1 | SUBSTITUTED 4-(QUINOLIN-2-YL-METHOXY)PHENYL-ACETIC-ACID DERIVATIVES | BAYER AG (DE) | 1993-04-14 | — | — | EP | disclosed |
| EP-0414019-A2 | Subsituted N-(quinolin-2-yl-methoxy)benzylsulfonylureas | BAYER AG (DE) | 1991-02-27 | — | — | EP | disclosed |
| EP-0387610-A2 | Substituted (quinolin-2-yl methoxy)phenyl-N,N'-sulphonyl ureas, processes for their preparation and their use in medicines | BAYER AG (DE) | 1990-09-19 | — | — | EP | disclosed |