Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902855 | 0.88 | KARS1 (0.40) | KARS1 | |
| SCHEMBL901702 | 0.87 | KARS1 (0.51) | KARS1FAAHSLC6A7LMNAMAPK1 | |
| SCHEMBL901736 | 0.82 | KARS1 (0.51) | KARS1 | |
| SCHEMBL901705 | 0.81 | P2RX7 (0.38) | LMNAMAPK1 | |
| SCHEMBL902032 | 0.78 | KARS1 (0.52) | KARS1 | |
| SCHEMBL901704 | 0.77 | CKS1B (0.48) | KARS1 | |
| SCHEMBL901245 | 0.76 | KARS1 (0.52) | KARS1 | |
| SCHEMBL901300 | 0.76 | KARS1 (0.49) | KARS1 | |
| SCHEMBL901409 | 0.76 | KARS1 (0.41) | KARS1 | |
| SCHEMBL901708 | 0.76 | KARS1 (0.66) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |