Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704584 | 0.89 | PARP1 (0.45) | KARS1TYK2WNT1GSK3BDYRK1A | |
| SCHEMBL1704237 | 0.83 | WNT1 (0.41) | KARS1WNT1GSK3BDYRK1A | |
| SCHEMBL1755675 | 0.83 | WNT1 (0.41) | KARS1WNT1GSK3BDYRK1A | |
| SCHEMBL12469310 | 0.82 | KARS1 (0.56) | KARS1TYK2MAP3K13MAP3K12 | |
| SCHEMBL901702 | 0.79 | KARS1 (0.51) | KARS1DYRK1A | |
| SCHEMBL901846 | 0.79 | KARS1 (0.46) | KARS1 | |
| SCHEMBL901300 | 0.79 | KARS1 (0.49) | KARS1 | |
| SCHEMBL901253 | 0.78 | KARS1 (0.65) | KARS1TYK2WNT1GSK3BDYRK1A | |
| SCHEMBL11963365 | 0.76 | HDAC1 (0.33) | KARS1TYK2GSK3BDYRK1AJAK1 | |
| SCHEMBL901885 | 0.76 | KARS1 (0.39) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |