Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30101062 | 0.86 | KDM4E (0.48) | KDM4EALDH1A1USP2LMNAMAPT | |
| SCHEMBL30533023 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1USP2LMNAMAPT | |
| SCHEMBL22780766 | 0.83 | KDM4E (0.53) | KDM4EALDH1A1USP2LMNAMAPT | |
| SCHEMBL2638947 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1USP2LMNAMAPT | |
| SCHEMBL8111393 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1USP2LMNAMAPT | |
| SCHEMBL2751685 | 0.79 | STS (0.53) | STSESR2CYP19A1CHKA | |
| SCHEMBL8866245 | 0.79 | KDM4E (0.54) | KDM4EALDH1A1USP2LMNAMAPT | |
| SCHEMBL21715808 | 0.78 | KDM4E (0.44) | KDM4EALDH1A1USP2LMNAMAPT | |
| SCHEMBL23915974 | 0.76 | KIF11 (0.52) | KDM4EALDH1A1USP2LMNAMAPT | |
| SCHEMBL21136501 | 0.76 | ALDH1A1 (0.56) | KDM4EALDH1A1USP2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0524781-B1 | Therapeutic amides | ZENECA LTD (GB) | 1996-03-27 | — | — | EP | disclosed |
| EP-0524781-A1 | Therapeutic amides | ZENECA LIMITED (GB) | 1993-01-27 | — | — | EP | disclosed |