Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902918 | 0.92 | KARS1 (0.58) | KARS1KDM4E | |
| SCHEMBL902991 | 0.91 | KARS1 (0.67) | KARS1TP53MEN1KMT2AKDM4E | |
| SCHEMBL1704905 | 0.90 | KARS1 (0.83) | KARS1TP53MEN1KMT2AKDM4E | |
| SCHEMBL902572 | 0.88 | KARS1 (0.69) | KARS1TP53MEN1KMT2AKDM4E | |
| SCHEMBL901397 | 0.87 | KARS1 (0.55) | KARS1KDM4E | |
| SCHEMBL901757 | 0.86 | KARS1 (0.66) | KARS1 | |
| SCHEMBL1704902 | 0.85 | KARS1 (0.73) | KARS1TP53MEN1KMT2AKDM4E | |
| SCHEMBL1704775 | 0.84 | KARS1 (0.57) | KARS1KDM4E | |
| SCHEMBL1704272 | 0.84 | KARS1 (0.74) | KARS1 | |
| SCHEMBL902079 | 0.83 | KARS1 (0.70) | KARS1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |