Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 18/20 | 0.55 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901758 | 0.91 | KARS1 (0.49) | SYKKARS1IDH2 | |
| SCHEMBL1704893 | 0.83 | KARS1 (0.61) | SYKKARS1 | |
| SCHEMBL1704909 | 0.83 | KARS1 (0.67) | SYKKARS1 | |
| SCHEMBL1705146 | 0.82 | SYK (0.57) | SYKKARS1 | |
| SCHEMBL901379 | 0.81 | KARS1 (0.64) | SYKKARS1 | |
| SCHEMBL902972 | 0.79 | KARS1 (0.51) | SYKKARS1 | |
| SCHEMBL1704940 | 0.79 | KARS1 (0.60) | KARS1 | |
| SCHEMBL1704625 | 0.79 | KARS1 (0.61) | SYKKARS1 | |
| SCHEMBL901426 | 0.78 | KARS1 (0.61) | SYKKARS1 | |
| SCHEMBL903001 | 0.77 | KARS1 (0.62) | SYKKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |