Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 17/20 | 0.47 |
| ▸ | IDH2 | P48735 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901980 | 0.91 | SYK (0.55) | KARS1SYKIDH2 | |
| SCHEMBL901783 | 0.82 | KARS1 (0.56) | KARS1SYK | |
| SCHEMBL901977 | 0.81 | KARS1 (0.65) | KARS1SYKIDH2 | |
| SCHEMBL1704409 | 0.80 | KARS1 (0.73) | KARS1SYK | |
| SCHEMBL901900 | 0.80 | KARS1 (0.53) | KARS1SYK | |
| SCHEMBL902079 | 0.79 | KARS1 (0.70) | KARS1 | |
| SCHEMBL901656 | 0.77 | KARS1 (0.63) | KARS1 | |
| SCHEMBL1704871 | 0.76 | KARS1 (0.44) | KARS1SYKIDH2 | |
| SCHEMBL901922 | 0.76 | ROCK1 (0.45) | SYKIDH2 | |
| SCHEMBL902092 | 0.76 | KARS1 (0.68) | KARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |