Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 5/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901940 | 0.92 | KMT2A (0.42) | KMT2ARXFP1KARS1POLBABL1 | |
| SCHEMBL901884 | 0.92 | KMT2A (0.42) | KMT2ARXFP1KARS1POLBABL1 | |
| SCHEMBL902167 | 0.86 | KMT2A (0.38) | KMT2ARXFP1KARS1POLBABL1 | |
| SCHEMBL902035 | 0.86 | KARS1 (0.48) | KARS1AURKANEK2JAK3SIRT2 | |
| SCHEMBL901364 | 0.78 | KARS1 (0.48) | KARS1SIRT2 | |
| SCHEMBL901722 | 0.74 | KARS1 (0.52) | KARS1AURKASRCNEK2SIRT2 | |
| SCHEMBL902197 | 0.73 | KARS1 (0.43) | KARS1SIRT2 | |
| SCHEMBL902681 | 0.71 | KARS1 (0.70) | KMT2AKARS1SRCALDH1A1MEN1 | |
| SCHEMBL901872 | 0.70 | KARS1 (0.52) | KMT2AKARS1GAASMN1; SMN2SIRT2 | |
| SCHEMBL901842 | 0.70 | KARS1 (0.54) | KARS1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |