Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 5/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901884 | 0.87 | KMT2A (0.42) | KMT2ARXFP1SYKKARS1POLB | |
| SCHEMBL901940 | 0.87 | KMT2A (0.42) | KMT2ARXFP1SYKKARS1POLB | |
| SCHEMBL902197 | 0.86 | KARS1 (0.43) | SYKKARS1 | |
| SCHEMBL901992 | 0.86 | KMT2A (0.42) | KMT2ARXFP1KARS1MEN1POLB | |
| SCHEMBL1704894 | 0.74 | KARS1 (0.50) | SYKKARS1MAPTALDH1A1 | |
| SCHEMBL901364 | 0.72 | KARS1 (0.48) | SYKKARS1 | |
| SCHEMBL902035 | 0.72 | KARS1 (0.48) | SYKKARS1 | |
| SCHEMBL10269155 | 0.71 | WNT3A (0.43) | SYKKARS1 | |
| SCHEMBL1704643 | 0.71 | MAPT (0.47) | KMT2ASYKKARS1MEN1MAPT | |
| SCHEMBL6872246 | 0.70 | FFAR1 (0.56) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |