Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 10/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901364 | 0.92 | KARS1 (0.48) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL902197 | 0.86 | KARS1 (0.43) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL901992 | 0.86 | KMT2A (0.42) | KARS1AURKASIRT2NEK2JAK3 | |
| SCHEMBL901722 | 0.78 | KARS1 (0.52) | KARS1AURKASIRT2JAK2JAK1 | |
| SCHEMBL901884 | 0.77 | KMT2A (0.42) | KARS1SYK | |
| SCHEMBL901940 | 0.77 | KMT2A (0.42) | KARS1SYK | |
| SCHEMBL901872 | 0.76 | KARS1 (0.52) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL902681 | 0.74 | KARS1 (0.70) | KARS1FYN | |
| SCHEMBL902167 | 0.72 | KMT2A (0.38) | KARS1SYK | |
| SCHEMBL1755645 | 0.71 | IKBKB (0.35) | AURKANEK2JAK3IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |