Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020638 | 0.90 | TDP1 (0.40) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9020543 | 0.86 | ATM (0.38) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9020444 | 0.81 | TDP1 (0.44) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9020356 | 0.81 | ALDH1A1 (0.43) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9020554 | 0.80 | ATM (0.46) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9020352 | 0.79 | CCR5 (0.42) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9399937 | 0.78 | CCR5 (0.45) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9020070 | 0.78 | CCR5 (0.43) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9020551 | 0.78 | NAAA (0.41) | TDP1ATMALDH1A1MAPTHPGD | |
| SCHEMBL9363138 | 0.76 | TDP1 (0.43) | TDP1ATMALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449191-B1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | BANYU PHARMA CO LTD (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5438054-A | Antibacterial agent | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-08-01 | — | — | US | disclosed |
| US-5374720-A | A thienamycins bactericides has nontoxic, side effect reduction against the kidney and central nervous system | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-12-20 | — | — | US | disclosed |
| EP-0449191-A1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |