Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | GABRE | P78334 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020874 | 0.79 | PNMT (0.44) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL9020793 | 0.77 | RAB9A (0.45) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL10033961 | 0.73 | NPC1 (0.50) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL6870022 | 0.72 | PNMT (0.54) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL9020390 | 0.71 | PNMT (0.37) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL6649917 | 0.68 | PNMT (0.38) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL1478686 | 0.67 | PNMT (0.52) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL28589725 | 0.67 | PNMT (0.45) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL18343747 | 0.67 | PNMT (0.45) | NPC1RAB9APNMTHTR7HTR2B | |
| SCHEMBL6650610 | 0.66 | PNMT (0.37) | NPC1RAB9APNMTHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669921-A4 | PREPARATION OF 2-ARYL CARBAPENEMS VIA A BORONIC ACID COUPLING REACTION. | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0669921-A1 | PREPARATION OF 2-ARYL CARBAPENEMS VIA A BORONIC ACID COUPLING REACTION | MERCK & CO. INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5442057-A | Preparation of 2-aryl carbapenems via a boronic acid coupling reaction | DECAMP ANN (US) | 1995-08-15 | — | — | US | disclosed |
| US-5338875-A | Boron containing intermediates useful in the preparation of carbapenems | MERCK & CO., INC. (US) | 1994-08-16 | — | — | US | disclosed |
| WO-1994011372-A1 | PREPARATION OF 2-ARYL CARBAPENEMS VIA A BORONIC ACID COUPLING REACTION | MERCK & CO., INC. (US) | 1994-05-26 | — | — | WO | disclosed |