Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020793 | 0.83 | RAB9A (0.45) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL9020401 | 0.79 | NPC1 (0.39) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL10033961 | 0.79 | NPC1 (0.50) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL1478686 | 0.75 | PNMT (0.52) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL18343747 | 0.71 | PNMT (0.45) | PNMTNPC1RAB9AHTR7HTR2B | |
| Boric Acid SCHEMBL28830312 | 0.70 | PNMT (0.47) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL30103334 | 0.70 | PNMT (0.63) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL524602 | 0.70 | PNMT (0.63) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL263230 | 0.68 | PNMT (0.68) | PNMTNPC1RAB9AHTR7HTR2B | |
| SCHEMBL2877998 | 0.68 | PNMT (0.61) | PNMTNPC1RAB9AHTR7HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0669921-A4 | PREPARATION OF 2-ARYL CARBAPENEMS VIA A BORONIC ACID COUPLING REACTION. | MERCK & CO INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0669921-A1 | PREPARATION OF 2-ARYL CARBAPENEMS VIA A BORONIC ACID COUPLING REACTION | MERCK & CO. INC. (US) | 1995-09-06 | — | — | EP | disclosed |
| US-5442057-A | Preparation of 2-aryl carbapenems via a boronic acid coupling reaction | DECAMP ANN (US) | 1995-08-15 | — | — | US | disclosed |
| US-5338875-A | Boron containing intermediates useful in the preparation of carbapenems | MERCK & CO., INC. (US) | 1994-08-16 | — | — | US | disclosed |
| WO-1994011372-A1 | PREPARATION OF 2-ARYL CARBAPENEMS VIA A BORONIC ACID COUPLING REACTION | MERCK & CO., INC. (US) | 1994-05-26 | — | — | WO | disclosed |