Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 6/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902044 | 0.72 | KARS1 (0.51) | FAAHMEN1ALDH1A1HTTKMT2A | |
| SCHEMBL901876 | 0.72 | KARS1 (0.71) | FAAHUSP2TSHRMEN1ALDH1A1 | |
| SCHEMBL901752 | 0.72 | KARS1 (0.73) | KARS1SLC6A7 | |
| SCHEMBL902003 | 0.72 | KARS1 (0.61) | FAAHKARS1LMNASLC6A7 | |
| SCHEMBL902071 | 0.69 | KARS1 (0.72) | KARS1 | |
| SCHEMBL902036 | 0.68 | KARS1 (0.81) | MEN1HTTKMT2AKARS1LMNA | |
| SCHEMBL1704270 | 0.68 | KARS1 (0.66) | FAAHKARS1 | |
| SCHEMBL901857 | 0.68 | KARS1 (0.57) | KARS1SLC6A7 | |
| SCHEMBL902013 | 0.67 | KARS1 (0.58) | KARS1 | |
| SCHEMBL901988 | 0.67 | KARS1 (0.55) | FAAHKARS1SLC6A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |