Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.51 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704429 | 0.87 | KARS1 (0.46) | KARS1ADORA2ASYKMEN1KMT2A | |
| SCHEMBL901813 | 0.85 | ALDH1A1 (0.40) | KARS1FAAHADORA2AADORA1ALDH1A1 | |
| SCHEMBL1704491 | 0.84 | KARS1 (0.70) | KARS1 | |
| SCHEMBL901752 | 0.84 | KARS1 (0.73) | KARS1 | |
| SCHEMBL901876 | 0.77 | KARS1 (0.71) | KARS1FAAHDHFRMEN1ALDH1A1 | |
| SCHEMBL901761 | 0.73 | KARS1 (0.54) | KARS1ALDH1A1 | |
| SCHEMBL901738 | 0.73 | KARS1 (0.58) | KARS1SYK | |
| SCHEMBL1704643 | 0.73 | MAPT (0.47) | KARS1SYKMEN1ALDH1A1KMT2A | |
| SCHEMBL902088 | 0.73 | KARS1 (0.56) | KARS1SYK | |
| SCHEMBL902064 | 0.72 | HDAC1 (0.42) | KARS1FAAHMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |