Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9020729 | 0.94 | CCR5 (0.42) | CCR5ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL9020004 | 0.90 | CCR5 (0.41) | CCR5ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL9399680 | 0.86 | CCR5 (0.42) | CCR5ALDH1A1MAPTHPGDATM | |
| SCHEMBL9020258 | 0.86 | ALDH1A1 (0.42) | CCR5ALDH1A1MAPTLMNAJAK2 | |
| SCHEMBL9021016 | 0.84 | CCR5 (0.46) | CCR5ALDH1A1MAPTLMNAJAK2 | |
| SCHEMBL9020556 | 0.83 | CCR5 (0.43) | CCR5ALDH1A1MAPTLMNAJAK2 | |
| SCHEMBL9399794 | 0.83 | CCR5 (0.48) | CCR5ALDH1A1MAPTLMNAJAK2 | |
| SCHEMBL9020407 | 0.81 | ALDH1A1 (0.41) | CCR5ALDH1A1MAPTHPGDATM | |
| SCHEMBL9020195 | 0.81 | ALDH1A1 (0.41) | CCR5ALDH1A1MAPTHPGDATM | |
| SCHEMBL9519199 | 0.80 | PREP (0.43) | CCR5ALDH1A1MAPTHPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449191-B1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | BANYU PHARMA CO LTD (JP) | 1996-07-03 | — | — | EP | disclosed |
| US-5438054-A | Antibacterial agent | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-08-01 | — | — | US | disclosed |
| US-5374720-A | A thienamycins bactericides has nontoxic, side effect reduction against the kidney and central nervous system | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-12-20 | — | — | US | disclosed |
| WO-1991014687-A1 | 2-(SUBSTITUTED PYRROLIDINYLTHIO)CARBAPENEM DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1991-10-03 | — | — | WO | disclosed |
| EP-0449191-A1 | 2-(Substituted pyrrolidinylthio)carbapenem derivatives | Banyu Pharmaceutical Co., Ltd. (JP) | 1991-10-02 | — | — | EP | disclosed |