Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 8/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.47 |
| ▸ | NQO2 | P16083 | 4/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19376952 | 0.81 | ADORA2A (0.53) | ADORA2BADORA2ANQO2ADORA1SRC | |
| SCHEMBL27985764 | 0.78 | HSP90AA1 (0.42) | ADORA2APIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL27985752 | 0.78 | ADORA2A (0.44) | ADORA2BADORA2ANQO2PIK3CDPIK3CA | |
| SCHEMBL901793 | 0.76 | ADORA2B (0.55) | ADORA2BADORA2ANQO2PIK3CDPIK3CA | |
| SCHEMBL1705644 | 0.72 | PIM1 (0.41) | PIM1PIM3PIM2 | |
| SCHEMBL22334571 | 0.69 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL17246864 | 0.69 | CYP19A1 (0.52) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL29683245 | 0.69 | CYP19A1 (0.52) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL24018528 | 0.67 | ALOX5AP (0.48) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG | |
| SCHEMBL30023117 | 0.67 | CYP19A1 (0.46) | PIK3CDPIK3CAPIK3CBPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |