Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902146 | 0.72 | ADORA2B (0.47) | PIM1PIM3PIM2 | |
| SCHEMBL902121 | 0.70 | KARS1 (0.50) | PIM1PIM3PIM2KARS1 | |
| SCHEMBL1704491 | 0.69 | KARS1 (0.70) | KARS1 | |
| SCHEMBL1704401 | 0.68 | KARS1 (0.52) | KARS1 | |
| SCHEMBL6352796 | 0.68 | HTR7 (0.71) | PIM1PIM3KARS1CHRNB2CHRNA4 | |
| SCHEMBL13092433 | 0.67 | PIM1 (0.67) | PIM1PIM3PIM2KARS1CHRNB2 | |
| SCHEMBL27985764 | 0.66 | HSP90AA1 (0.42) | PIM1PIM3PIM2DHFR | |
| SCHEMBL6348853 | 0.66 | CHRNB2 (0.61) | PIM1PIM3PIM2CHRNB2CHRNA4 | |
| SCHEMBL6351651 | 0.66 | ADRB2 (0.61) | PIM1PIM3CHRNB2CHRNA4CHRNA1 | |
| SCHEMBL12205345 | 0.65 | CHRNB2 (0.75) | CHRNB2CHRNA4CHRNA1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |