Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9021623 | 0.91 | DRD2 (0.68) | OPRK1CYP2D6CYP2C19DRD2SIGMAR1 | |
| SCHEMBL9021904 | 0.87 | DRD2 (0.62) | CYP2D6CYP2C19DRD2SIGMAR1L3MBTL1 | |
| SCHEMBL9021398 | 0.85 | OPRK1 (0.53) | OPRK1USP2 | |
| SCHEMBL9021718 | 0.82 | OPRK1 (0.50) | OPRK1USP2ALDH1A1 | |
| SCHEMBL9021924 | 0.80 | TDP1 (0.54) | OPRK1USP2KMT2AALDH1A1 | |
| SCHEMBL9021741 | 0.78 | CXCR6 (0.53) | DRD2 | |
| SCHEMBL9022015 | 0.77 | TSHR (0.49) | OPRK1CYP2D6DRD2 | |
| SCHEMBL10812960 | 0.76 | KMT2A (0.72) | OPRK1CYP2D6CYP2C19USP2L3MBTL1 | |
| SCHEMBL9021529 | 0.75 | TSHR (0.48) | OPRK1DRD2 | |
| SCHEMBL9021580 | 0.75 | TSHR (0.47) | OPRK1CYP2D6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640601-B1 | BENZAMIDE DERIVATIVE | HOKURIKU PHARMACEUTICAL (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5500422-A | FOR TREATING GASTROINTESTINAL DISEASES | HOKURIKU SEIYAKU CO. LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| US-5395832-A | Gastrointestinal disorders | HOKURIKU SEIYAKU CO., LTD. (JP) | 1995-03-07 | — | — | US | disclosed |
| EP-0640601-A1 | BENZAMIDE DERIVATIVE | HOKURIKU SEIYAKU CO., LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |