Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 16/20 | 0.80 |
| ▸ | LTB4R2 | Q9NPC1 | 15/20 | 0.80 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29396901 | 0.89 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL1894401 | 0.89 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL9022847 | 0.81 | LTB4R (0.84) | LTB4RLTB4R2 | |
| SCHEMBL9023332 | 0.80 | LTB4R (0.83) | LTB4RLTB4R2 | |
| SCHEMBL1894403 | 0.79 | LTB4R (0.69) | LTB4RLTB4R2MRGPRX4 | |
| SCHEMBL10695839 | 0.75 | ALOX5 (0.61) | LTB4RLTB4R2ALOX5 | |
| SCHEMBL7959149 | 0.73 | LTB4R (0.60) | LTB4RLTB4R2MRGPRX4 | |
| SCHEMBL9023836 | 0.73 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL9023608 | 0.73 | LTB4R (1.00) | LTB4RLTB4R2 | |
| SCHEMBL14021678 | 0.72 | LTB4R (0.81) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548250-B1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE POULENC RORER INT (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0548250-A4 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY | — | 1993-10-27 | — | — | EP | disclosed |
| EP-0548250-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY. | RHONE POULENC RORER INT (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004321-A1 | SUBSTITUTED BICYCLIC ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B4 ANTAGONIST ACTIVITY | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-03-19 | — | — | WO | disclosed |