Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ADH1B | P00325 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
| ▸ | ADH4 | P08319 | 1/20 | 0.30 |
| ▸ | ADH7 | P40394 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7684881 | 0.79 | CYP1A2 (0.39) | CHRM5ADRA2CCHRM2CHRM4CHRM1 | |
| SCHEMBL9821146 | 0.69 | CHRM5 (0.33) | CHRM5ADRA2CCHRM2CHRM4CHRM1 | |
| SCHEMBL7414222 | 0.68 | HSD11B1 (0.35) | CHRM5ADRA2CCHRM2CHRM4CHRM1 | |
| SCHEMBL1431683 | 0.67 | USP2 (0.37) | — | |
| SCHEMBL9518336 | 0.66 | ALDH1A1 (0.31) | — | |
| SCHEMBL17982081 | 0.66 | ALDH1A1 (0.31) | — | |
| SCHEMBL22330665 | 0.65 | CHRM5 (0.31) | CHRM5ADRA2CCHRM2CHRM4CHRM1 | |
| SCHEMBL11849600 | 0.65 | SIGMAR1 (0.33) | CHRM5ADRA2CCHRM2CHRM4CHRM1 | |
| SCHEMBL4814952 | 0.65 | CYP1A2 (0.36) | CHRM5ADRA2CCHRM2CHRM4CHRM1 | |
| SCHEMBL7452334 | 0.65 | ADH1B (0.39) | ADH1BADH1CADH1AADH4ADH7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0619819-B1 | 1-ARYLHETEROARYLALKYL SUBSTITUTED-1H-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 1996-06-12 | — | — | EP | claimed |