Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GRK6 | P43250 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1609693 | 0.80 | LCK (0.63) | LCKFYNALDH1A1TP53KDM4E | |
| SCHEMBL14273079 | 0.78 | CYP1A2 (0.56) | CYP1A2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1417516 | 0.75 | LCK (0.72) | LCKFYNALDH1A1KDM4EMEN1 | |
| SCHEMBL30415497 | 0.75 | LCK (0.72) | LCKFYNALDH1A1KDM4EMEN1 | |
| SCHEMBL11208688 | 0.75 | APEX1 (0.56) | ALDH1A1EGFRERBB2KDM4EMAPT | |
| SCHEMBL11800701 | 0.74 | HSD17B10 (0.59) | LCKFYNCYP1A2ALDH1A1TP53 | |
| SCHEMBL14218245 | 0.74 | CYP1A2 (0.53) | CYP1A2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL342810 | 0.72 | ALDH1A1 (0.53) | CYP1A2ALDH1A1MAPTSMN1; SMN2CYP3A4 | |
| SCHEMBL7419329 | 0.72 | MTNR1A (0.56) | CYP1A2ALDH1A1KDM4EHSD17B10NPC1 | |
| SCHEMBL21624243 | 0.72 | LCK (0.53) | LCKFYNCYP1A2ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543584-B1 | Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system | LILLY INDUSTRIES LTD (GB) | 1996-05-22 | — | — | EP | disclosed |
| US-5338735-A | For treatment of central nervous system disorders | LILLY INDUSTRIES LIMITED (GB) | 1994-08-16 | — | — | US | disclosed |
| EP-0543584-A1 | Benzo(b)thiophene-2-carboxamides for the treatment of disorders of the central nervous system | LILLY INDUSTRIES LIMITED (GB) | 1993-05-26 | — | — | EP | disclosed |
| US-3976780-A | Methods of protection against emesis in mammals by administration of a 3-alkoxy-thianaphthene-2-carboxamide | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES L'ILE-DE-FRANCE (FR) | 1976-08-24 | — | — | US | disclosed |
| US-3954748-A | ANTIEMETICS | SOCIETE D'ETUDES SCIENTIFIQUES ET INDUSTRIELLES DE L'ILE-DE-FRANCE (FR) | 1976-05-04 | — | — | US | disclosed |