Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 7/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023851 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTGFERITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL9023738 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTGFERITGB3ITGA2B | |
| SCHEMBL9024346 | 0.79 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTGFERITGB3ITGA2B | |
| SCHEMBL9024669 | 0.79 | ITGB3 (0.60) | SMN1; SMN2MAPTGFERITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL9023772 | 0.78 | ITGB3 (0.59) | SMN1; SMN2MAPTGFERITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL9024564 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTGFERITGB3ITGA2B | |
| SCHEMBL13601439 | 0.72 | POLB (0.43) | SMN1; SMN2MAPTHRH3TSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL9177574 | 0.71 | ITGB3 (0.45) | SMN1; SMN2MAPTGFERITGB3ITGA2B | |
| SCHEMBL9023914 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTGFERROCK2CYP46A1 | |
| SCHEMBL9023588 | 0.70 | DPP7 (0.67) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718287-A2 | Piperazine derivatives, medicaments containing them, their use, and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1996-06-26 | — | — | EP | disclosed |