Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8838094 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTGFERCYP46A1TRPV1 | |
| SCHEMBL9023933 | 0.88 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTGFERDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9024246 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPTGFERDRD2DRD3 | |
| SCHEMBL9409461 | 0.85 | DRD2 (0.48) | DRD2DRD3CYP46A1GAA | |
| SCHEMBL9023851 | 0.85 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTGFERCYP46A1TRPV1 | |
| Hydrochloric Acid SCHEMBL9023736 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTGFERCYP46A1TRPV1 | |
| Hydrochloric Acid SCHEMBL9023569 | 0.77 | HTR7 (0.48) | MAPTDRD2DRD3KDM4EHIF1A | |
| SCHEMBL9023680 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTGFERCYP46A1TRPV1 | |
| SCHEMBL9024669 | 0.75 | ITGB3 (0.60) | SMN1; SMN2MAPTGFERCYP46A1TRPV1 | |
| SCHEMBL9024346 | 0.75 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTGFERDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718287-A2 | Piperazine derivatives, medicaments containing them, their use, and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1996-06-26 | — | — | EP | claimed |
| EP-0718287-A2 | Piperazine derivatives, medicaments containing them, their use, and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1996-06-26 | — | — | EP | disclosed |