Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187940 | 0.82 | ALDH1A1 (0.54) | KDM4EHSD17B10ALDH1A1PDE4APDE4B | |
| SCHEMBL6608296 | 0.79 | GRK6 (0.45) | KDM4EHSD17B10ALDH1A1GAAMPI | |
| SCHEMBL1250505 | 0.78 | NOX1 (0.49) | GAAGFER | |
| SCHEMBL10765716 | 0.78 | KDM4E (0.40) | KDM4EHSD17B10ALDH1A1PDE4APDE4B | |
| SCHEMBL705661 | 0.78 | MAPT (0.49) | KDM4EHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL3044550 | 0.78 | HSD17B10 (0.47) | KDM4EHSD17B10ALDH1A1GAATDP1 | |
| SCHEMBL7462417 | 0.76 | CFD (0.44) | KDM4EHSD17B10ALDH1A1HPGDTDP1 | |
| SCHEMBL6789801 | 0.76 | DHFR (0.44) | KDM4EHSD17B10ALDH1A1GAAMPI | |
| SCHEMBL3588740 | 0.75 | MAPT (0.44) | KDM4EHPGDGAA | |
| SCHEMBL7001543 | 0.75 | PARP1 (0.37) | KDM4EHSD17B10ALDH1A1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0720609-A1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008549-A1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 1995-03-30 | — | — | WO | disclosed |