Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9024250 | 0.99 | KCNH2 (0.43) | KCNH2HTR7HTR1ADRD2DRD4 | |
| SCHEMBL9024282 | 0.88 | HTR7 (0.42) | HTR7HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL9024511 | 0.87 | HTR7 (0.41) | HTR7DRD2DRD4DRD3 | |
| SCHEMBL9024561 | 0.85 | HTR1A (0.45) | HTR7HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9024223 | 0.84 | HTR2C (0.50) | HTR7HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9688546 | 0.82 | HTR2C (0.56) | HTR7HTR1ADRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL9023951 | 0.82 | HTR2C (0.55) | HTR7HTR1ADRD2DRD4DRD3 | |
| SCHEMBL9024541 | 0.80 | HTR1A (0.53) | KCNH2HTR7HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9024851 | 0.80 | HTR1A (0.52) | KCNH2HTR7HTR1ADRD2DRD3 | |
| SCHEMBL9024721 | 0.80 | ADRA1A (0.42) | HTR7HTR1ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114936-A | Antipsychotic and analgesic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-19 | — | — | US | claimed |
| EP-0474012-B1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5256672-A | Antipsychotic, analgesic | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-10-26 | — | — | US | disclosed |
| US-5180834-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-01-19 | — | — | US | disclosed |
| US-5114936-A | Antipsychotic and analgesic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-19 | — | — | US | disclosed |
| EP-0474012-A1 | 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-03-11 | — | — | EP | disclosed |