Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HMGCR | P04035 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023825 | 0.94 | LMNA (0.45) | LMNAKMT2AMEN1CYP1A2APP | |
| SCHEMBL9025222 | 0.93 | LMNA (0.47) | LMNAKMT2AMEN1CYP1A2APP | |
| SCHEMBL9024146 | 0.88 | L3MBTL1 (0.45) | LMNAKMT2AMEN1CYP1A2HMGCR | |
| SCHEMBL9024831 | 0.86 | ALDH1A1 (0.54) | KMT2AMEN1CYP1A2POLBSMN1; SMN2 | |
| SCHEMBL3209384 | 0.85 | POLB (0.62) | LMNAKMT2AMEN1APPPOLB | |
| SCHEMBL9449849 | 0.83 | LMNA (0.55) | LMNAKMT2AMEN1CYP1A2SMN1; SMN2 | |
| SCHEMBL6199939 | 0.81 | KMT2A (0.52) | LMNAKMT2AMEN1CYP1A2POLB | |
| SCHEMBL3513032 | 0.80 | MEN1 (0.44) | LMNAKMT2AMEN1CYP1A2POLB | |
| SCHEMBL18297785 | 0.79 | ALDH1A1 (0.56) | LMNAKMT2AMEN1CYP1A2APP | |
| SCHEMBL20564610 | 0.79 | PDE4A (0.38) | LMNAKMT2AMEN1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012114252-A1 | NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES | ACTELION PHARMACEUTICALS LTD (CH) | 2012-08-30 | — | — | WO | disclosed |
| EP-0398179-B1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO (JP) | 1996-01-17 | — | — | EP | disclosed |
| US-5116855-A | Aldose reductase inhibitors; antidiabetic agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0398179-A1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-11-22 | — | — | EP | disclosed |