Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025023 | 0.80 | L3MBTL1 (0.50) | KMT2ASMN1; SMN2MEN1ABCB1PARP1 | |
| SCHEMBL9024060 | 0.78 | KDM4E (0.51) | KMT2APARP1HPGDKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7394609 | 0.76 | HTR4 (0.77) | KMT2ASMN1; SMN2MEN1KCNH2HTR4 | |
| Hydrochloric Acid SCHEMBL7394611 | 0.76 | KMT2A (0.64) | KMT2ASMN1; SMN2MEN1ABCB1PARP1 | |
| SCHEMBL14584165 | 0.74 | MEN1 (0.57) | KMT2ASMN1; SMN2MEN1ABCB1PARP1 | |
| SCHEMBL7389168 | 0.73 | WNT1 (0.67) | KMT2ASMN1; SMN2MEN1ABCB1KDM4E | |
| SCHEMBL24273601 | 0.73 | ABCB1 (0.65) | KMT2ASMN1; SMN2MEN1ABCB1PARP1 | |
| SCHEMBL17883693 | 0.73 | CNR2 (0.57) | KMT2ASMN1; SMN2MEN1HPGDKDM4E | |
| SCHEMBL9023887 | 0.71 | GLA (0.47) | KMT2AMEN1HPGDKDM4EALDH1A1 | |
| SCHEMBL9525651 | 0.70 | SMN1; SMN2 (0.60) | KMT2ASMN1; SMN2MEN1ABCB1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |