Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | NQO2 | P16083 | 3/20 | 0.44 |
| ▸ | NQO1 | P15559 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | POLR1A | O95602 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025070 | 0.85 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDHSD17B10EGFR | |
| SCHEMBL9024672 | 0.80 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDPARP1POLR1A | |
| SCHEMBL9024197 | 0.78 | KMT2A (0.62) | KDM4EALDH1A1HPGDHSD17B10PARP1 | |
| SCHEMBL9738372 | 0.77 | NQO2 (0.46) | KDM4EALDH1A1HPGDHSD17B10NQO2 | |
| SCHEMBL9023887 | 0.75 | GLA (0.47) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL9025371 | 0.68 | CYP1A2 (0.44) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL9157388 | 0.66 | HDAC1 (0.61) | KDM4EALDH1A1HPGDHSD17B10EGFR | |
| SCHEMBL2725699 | 0.66 | NQO1 (0.39) | KDM4EALDH1A1NQO2NQO1TSHR | |
| SCHEMBL9024487 | 0.66 | ABCB1 (0.42) | KDM4EALDH1A1NQO2NQO1TSHR | |
| SCHEMBL15438867 | 0.66 | POLB (0.55) | ALDH1A1POLBKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |