Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025106 | 0.84 | ALDH1A1 (0.46) | SMN1; SMN2HPGDRAB9AMAPTMEN1 | |
| SCHEMBL9023430 | 0.78 | HPGD (0.40) | HPGDMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL9024624 | 0.78 | PTGS2 (0.50) | MAPTMEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL8284596 | 0.76 | RAB9A (0.60) | SMN1; SMN2HPGDRAB9AMAPTGAA | |
| SCHEMBL9024894 | 0.75 | PPARG (0.43) | SMN1; SMN2MAPTMEN1KMT2ALMNA | |
| SCHEMBL162301 | 0.73 | ALDH1A1 (0.37) | SMN1; SMN2HPGDRAB9AMEN1KMT2A | |
| SCHEMBL14624903 | 0.72 | BCHE (0.55) | RAB9AMAPTGAAMEN1KMT2A | |
| SCHEMBL21268196 | 0.71 | SMN1; SMN2 (0.41) | SMN1; SMN2HPGDRAB9AMEN1KMT2A | |
| SCHEMBL2565533 | 0.71 | KMT2A (0.40) | SMN1; SMN2MAPTMEN1KMT2APOLB | |
| SCHEMBL7511668 | 0.70 | CYP2C19 (0.40) | MAPTMEN1KMT2AL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398179-B1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO (JP) | 1996-01-17 | — | — | EP | disclosed |
| US-5116855-A | Aldose reductase inhibitors; antidiabetic agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0398179-A1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-11-22 | — | — | EP | disclosed |