Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL324953 | 0.81 | TDP1 (0.49) | PTGDRPTGDR2KMT2AMAPTALDH1A1 | |
| SCHEMBL9023430 | 0.81 | HPGD (0.40) | PTGS2LMNACYP1A2CYP2C9KMT2A | |
| SCHEMBL9024232 | 0.78 | SMN1; SMN2 (0.41) | PTGS2LMNACYP1A2KMT2AMAPT | |
| SCHEMBL9024894 | 0.77 | PPARG (0.43) | LMNACYP1A2CYP2C9KMT2AKDM4E | |
| SCHEMBL9024538 | 0.77 | ALDH1A1 (0.46) | LMNACYP1A2CYP2C9KMT2AKDM4E | |
| SCHEMBL9023743 | 0.74 | LMNA (0.53) | PTGS2LMNAPTGDRPTGDR2CYP1A2 | |
| SCHEMBL9111454 | 0.74 | PTPN1 (0.32) | — | |
| SCHEMBL5120243 | 0.74 | PTGS2 (0.81) | PTGS2LMNACYP1A2CYP2C9KMT2A | |
| SCHEMBL2565533 | 0.73 | KMT2A (0.40) | PTGS2LMNACYP1A2KMT2AKDM4E | |
| SCHEMBL162984 | 0.73 | NQO1 (0.36) | LMNAKMT2AKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0398179-B1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO (JP) | 1996-01-17 | — | — | EP | disclosed |
| US-5116855-A | Aldose reductase inhibitors; antidiabetic agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0398179-A1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-11-22 | — | — | EP | disclosed |