Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 3/20 | 0.38 |
| ▸ | NQO1 | P15559 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727878 | 0.90 | SMN1; SMN2 (0.44) | NCF1PIM1PIM3PIM2KMT2A | |
| Hydrochloric Acid SCHEMBL1641765 | 0.89 | SMN1; SMN2 (0.43) | NCF1PIM1PIM3PIM2KMT2A | |
| SCHEMBL15585982 | 0.83 | NCF1 (0.47) | NCF1ALDH1A1NPSR1HRH3SLC2A1 | |
| SCHEMBL6815177 | 0.81 | ALDH1A1 (0.49) | NCF1ALDH1A1NPSR1HRH3KMT2A | |
| SCHEMBL14924462 | 0.81 | NCF1 (0.43) | NCF1ALDH1A1NPSR1KMT2ANQO2 | |
| SCHEMBL23797765 | 0.81 | IDO1 (0.39) | ALDH1A1KMT2ANQO2ADRA2B | |
| SCHEMBL23709737 | 0.80 | FERMT2 (0.41) | ALDH1A1ADRA2B | |
| SCHEMBL9023734 | 0.80 | POLB (0.43) | NCF1ALDH1A1NPSR1HRH3KMT2A | |
| SCHEMBL3927672 | 0.79 | NCF1 (0.43) | NCF1ALDH1A1NPSR1HRH3KMT2A | |
| SCHEMBL18403936 | 0.79 | ADRA2B (0.37) | ALDH1A1PIM1NQO2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108101926-A | Pyrimido five-membered heterocycles containing quinolinone, preparation method and applications | 郑州大学 | 2018-06-01 | — | — | CN | disclosed |
| EP-2585470-B1 | NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHIBITION OF TYROSINE KINASE ACTIVITY | HANMI SCIENCE CO LTD (KR) | 2017-01-25 | — | — | EP | disclosed |
| EP-2975042-A1 | NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHIBITION OF TYROSINE KINASE ACTIVITY | Boehringer Ingelheim International GmbH (DE) | 2016-01-20 | — | — | EP | disclosed |
| WO-2011162515-A2 | NOVEL FUSED PYRIMIDINE DERIVATIVES FOR INHD3ITION OF TYROSINE KINASE ACTIVITY | HANMI HOLDINGS CO. , LTD. (KR) | 2011-12-29 | — | — | WO | disclosed |
| EP-0544400-B1 | P-Phenylenediamine substituted by a quaternary ammonium group and an electron withdrawing group | BRISTOL MYERS SQUIBB CO (US) | 1996-03-13 | — | — | EP | disclosed |
| EP-0544400-A2 | P-Phenylenediamine substituted by a quaternary ammonium group and an electron withdrawing group | Bristol-Myers Squibb Company (US) | 1993-06-02 | — | — | EP | disclosed |
| US-5198584-A | Developers for hair dyes | CLAIROL INC. (US) | 1993-03-30 | — | — | US | disclosed |
| US-5139532-A | In a tinctorially effective hair dye developer also containing and an adjuvant selected from surfactans, alkalizing agents, thickeners, chealting agents and perfumes | CLAIROL, INC. (US) | 1992-08-18 | — | — | US | disclosed |